Reactome | SLC25A1 may exchange mitochondrial PEP for cytosolic anion

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SLC25A1 may exchange mitochondrial PEP for cytosolic anion Show undefined attributes

catalystActivity	[CatalystActivity:10231964] tricarboxylic acid transmembrane transporter activity of SLC25A1 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10249024
displayName	SLC25A1 may exchange mitochondrial PEP for cytosolic anion
eventOf	[Pathway:R-CFA-428643] Organic anion transport by SLC5/17/25 transporters - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG - Canis familiaris
inferredFrom	[Reaction:R-HSA-372449] SLC25A1 may exchange mitochondrial PEP for cytosolic anion - Homo sapiens
input	[SimpleEntity:R-ALL-1454930] organic anion [cytosol] [SimpleEntity:R-ALL-372364] PEP [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A1 may exchange mitochondrial PEP for cytosolic anion phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]
output	[SimpleEntity:R-ALL-9815686] organic anion [mitochondrial matrix] [SimpleEntity:R-ALL-29492] PEP [cytosol]
precedingEvent	[Reaction:R-CFA-372819] PCK2 phosphorylates OA to yield PEP - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-372449
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-428643] Organic anion transport by SLC5/17/25 transporters
(precedingEvent)	[Reaction:R-CFA-70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG
(inferredTo)	[Reaction:R-HSA-372449] SLC25A1 may exchange mitochondrial PEP for cytosolic anion

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