Reactome | Caspase-3 [cytosol]

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Caspase-3 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10258335] cysteine-type endopeptidase activator activity involved in apoptotic process of Caspase-3 [cytosol] [CatalystActivity:10244668] cysteine-type endopeptidase activity of Caspase-3 [cytosol] [CatalystActivity:10249211] aspartic-type endopeptidase activity of Caspase-3 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-114304] XIAP:Caspase-3 [cytosol] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-211219] Translocation of caspase-3 to the nucleus - Canis familiaris [Reaction:R-CFA-9627104] XIAP binds CASP3 - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10234597
displayName	Caspase-3 [cytosol]
hasComponent	2 × [Complex:R-CFA-350888] CASP3(29-175):CASP3(176-277) [cytosol]
inDisease	false
inferredFrom	[DefinedSet:R-HSA-205013] Active Caspases 2, 3 [cytosol] - Homo sapiens [Complex:R-HSA-350870] Caspase-3 [cytosol] - Homo sapiens
maxDepth	3
memberOf	[DefinedSet:R-CFA-202877] Caspase-3, Caspase-7 [cytosol] - Canis familiaris
name	Caspase-3
negativelyRegulates	[NegativeRegulation:10319472] Negative regulation by 'Caspase-3 [cytosol]'
producedByEvent	[Reaction:R-CFA-205117] p75NTR:NADE promotes caspase2/3 activation - Canis familiaris [Reaction:R-CFA-114252] Cleavage of Procaspase-3 by the apoptosome - Canis familiaris [Reaction:R-CFA-418845] Activation of caspase-3 - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-350870
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-CFA-205117] p75NTR:NADE promotes caspase2/3 activation [Reaction:R-CFA-114252] Cleavage of Procaspase-3 by the apoptosome [Reaction:R-CFA-418845] Activation of caspase-3
(inferredTo)	[DefinedSet:R-HSA-205013] Active Caspases 2, 3 [cytosol] [Complex:R-HSA-350870] Caspase-3 [cytosol]
(regulator)	[NegativeRegulation:10319472] Negative regulation by 'Caspase-3 [cytosol]'
(physicalEntity)	[CatalystActivity:10258335] cysteine-type endopeptidase activator activity involved in apoptotic process of Caspase-3 [cytosol] [CatalystActivity:10244668] cysteine-type endopeptidase activity of Caspase-3 [cytosol] [CatalystActivity:10249211] aspartic-type endopeptidase activity of Caspase-3 [cytosol]
(input)	[Reaction:R-CFA-9627104] XIAP binds CASP3 [Reaction:R-CFA-211219] Translocation of caspase-3 to the nucleus
(hasMember)	[DefinedSet:R-CFA-202877] Caspase-3, Caspase-7 [cytosol]
(hasComponent)	[Complex:R-CFA-114304] XIAP:Caspase-3 [cytosol]

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