Reactome | Factor I cleaves iC3b

Schema > Reaction > Entries

Factor I cleaves iC3b Show undefined attributes

catalystActivity	[CatalystActivity:10282415] serine-type endopeptidase activity of CFI [extracellular region]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10282417
displayName	Factor I cleaves iC3b
eventOf	[Pathway:R-CFA-977606] Regulation of Complement cascade - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3266557] Factor I cleaves iC3b - Homo sapiens
input	[Complex:R-CFA-3266508] CR1:iC3b [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Factor I cleaves iC3b
output	[EntityWithAccessionedSequence:R-CFA-3266505] C3 [plasma membrane] [Complex:R-CFA-3266497] C3c [extracellular region] [EntityWithAccessionedSequence:R-CFA-977369] LOC490269 [plasma membrane]
precedingEvent	[Reaction:R-CFA-977615] Factor I inactivates MCP/CR1-bound C4b/C3b - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-3266557
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-977606] Regulation of Complement cascade
(inferredTo)	[Reaction:R-HSA-3266557] Factor I cleaves iC3b