Reactome | Autophosphorylation of BTK/ITK

Schema > Reaction > Entries

Autophosphorylation of BTK/ITK Show undefined attributes

catalystActivity	[CatalystActivity:10280648] protein tyrosine kinase activity of p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10280650
displayName	Autophosphorylation of BTK/ITK
eventOf	[Pathway:R-CFA-2871809] FCERI mediated Ca+2 mobilization - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2730858] Autophosphorylation of BTK/ITK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-2685675] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Autophosphorylation of BTK/ITK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-2685650] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane]
precedingEvent	[Reaction:R-CFA-2730833] Phosphorylation of TEC kinases by p-SYK - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2730858
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2871809] FCERI mediated Ca+2 mobilization
(inferredTo)	[Reaction:R-HSA-2730858] Autophosphorylation of BTK/ITK