Reactome | RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels

Schema > Reaction > Entries

RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels Show undefined attributes

catalystActivity	[CatalystActivity:10280404] ubiquitin-protein transferase activity of RAF1:SGK:TSC22D3:WPP [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10280418
displayName	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
eventOf	[Pathway:R-CFA-2672351] Stimuli-sensing channels - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-2672342] SCNN channels [plasma membrane] 6 × [DefinedSet:R-CFA-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-947590] Pi [plasma membrane] [Complex:R-CFA-2684917] Ub-SCNN channels [plasma membrane]
regulatedBy	[PositiveRegulation:10280419] Positive regulation by 'WNKs [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2682349
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2672351] Stimuli-sensing channels
(inferredTo)	[Reaction:R-HSA-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels

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