Reactome | PARP1 binds SMAD2/3:SMAD4 heterotrimer

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PARP1 binds SMAD2/3:SMAD4 heterotrimer Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10278000
displayName	PARP1 binds SMAD2/3:SMAD4 heterotrimer
eventOf	[Pathway:R-CFA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Canis familiaris
inferredFrom	[Reaction:R-HSA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Homo sapiens
input	[DefinedSet:R-CFA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-201568] PARP1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PARP1 binds SMAD2/3:SMAD4 heterotrimer
output	[Complex:R-CFA-2187322] p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-CFA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2187330
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)	[Reaction:R-CFA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4
(inferredTo)	[Reaction:R-HSA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer

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