Reactome | Hyaluronan degradation

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Hyaluronan degradation Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330909
displayName	Hyaluronan degradation
eventOf	[Pathway:R-CFA-2142845] Hyaluronan metabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21629] hyaluronan catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-5693356] CEMIP hydrolyzes HA - Canis familiaris [BlackBoxEvent:R-CFA-9941055] SPAM1 randomly cleaves HA - Canis familiaris [Reaction:R-CFA-2160884] HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ - Canis familiaris [BlackBoxEvent:R-CFA-2160892] HYAL2 hydrolyses HA into 20kDa fragments - Canis familiaris [BlackBoxEvent:R-CFA-2160874] HYAL1 hydrolyses (HA)50 - Canis familiaris [Reaction:R-CFA-2162227] GUSB tetramer hydrolyses (HA)2 - Canis familiaris [Reaction:R-CFA-2162225] HEXA cleaves the terminal GlcNAc from small HA fragments - Canis familiaris [Reaction:R-CFA-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Canis familiaris [Reaction:R-CFA-2162226] GUSB tetramer hydrolyzes GlcA-?1,3-GlcNAc - Canis familiaris [Reaction:R-CFA-2162229] SLC17A5 exports GlcA from the lysosome to the cytosol - Canis familiaris
inferredFrom	[Pathway:R-HSA-2160916] Hyaluronan degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Hyaluronan degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-2160916
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2142845] Hyaluronan metabolism
(inferredTo)	[Pathway:R-HSA-2160916] Hyaluronan degradation

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