Reactome | The p75NTR C-terminal fragment enters endosomes

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The p75NTR C-terminal fragment enters endosomes Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10246817
displayName	The p75NTR C-terminal fragment enters endosomes
eventOf	[Pathway:R-CFA-193692] Regulated proteolysis of p75NTR - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-193682] gamma-secretase cleaves the p75NTR transmembrane domain - Canis familiaris
inferredFrom	[Reaction:R-HSA-209532] The p75NTR C-terminal fragment enters endosomes - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-194476] NGFR [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The p75NTR C-terminal fragment enters endosomes
output	[EntityWithAccessionedSequence:R-CFA-209541] NGFR [endosome]
precedingEvent	[Reaction:R-CFA-193679] alpha-secretase cleaves the p75NTR extracellular domain - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-209532
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-193692] Regulated proteolysis of p75NTR
(precedingEvent)	[Reaction:R-CFA-193682] gamma-secretase cleaves the p75NTR transmembrane domain
(inferredTo)	[Reaction:R-HSA-209532] The p75NTR C-terminal fragment enters endosomes

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