Reactome | EXT1:EXT2 transfers GlcA to heparan

Schema > Reaction > Entries

EXT1:EXT2 transfers GlcA to heparan Show undefined attributes

catalystActivity	[CatalystActivity:10274780] N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity of EXT1:EXT2 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10276030
displayName	EXT1:EXT2 transfers GlcA to heparan
eventOf	[Pathway:R-CFA-2022928] HS-GAG biosynthesis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
inferredFrom	[Reaction:R-HSA-2076392] EXT1:EXT2 transfers GlcA to heparan - Homo sapiens
input	[DefinedSet:R-CFA-2076412] Heparan(2)-PGs [Golgi lumen] [SimpleEntity:R-ALL-1889970] UDP-GlcA [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	EXT1:EXT2 transfers GlcA to heparan Another GlcA addition extends the heparan chain
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-CFA-2076535] Heparan(3)-PGs [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-CFA-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2076392
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2022928] HS-GAG biosynthesis
(precedingEvent)	[Reaction:R-CFA-2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan
(inferredTo)	[Reaction:R-HSA-2076392] EXT1:EXT2 transfers GlcA to heparan

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