Reactome | Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA

Schema > Reaction > Entries

Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10275737] acyl-CoA 6-desaturase activity of FADS2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10275771
displayName	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA
eventOf	[Pathway:R-CFA-2046105] Linoleic acid (LA) metabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2046093] Translocation of tetracosapentaenoyl-CoA to peroxisomes - Canis familiaris
inferredFrom	[Reaction:R-HSA-2046097] Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA - Homo sapiens
input	2 × [SimpleEntity:R-ALL-194697] NADH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2046048] TTA-CoA [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA
output	2 × [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-194653] NAD+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2046050] TPA-CoA [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-CFA-2046095] Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2046097
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2046105] Linoleic acid (LA) metabolism
(precedingEvent)	[Reaction:R-CFA-2046093] Translocation of tetracosapentaenoyl-CoA to peroxisomes
(inferredTo)	[Reaction:R-HSA-2046097] Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA

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