Reactome | Calcineurin binds NFATC1,2,3

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10275166
displayName	Calcineurin binds NFATC1,2,3
eventOf	[Pathway:R-CFA-2025928] Calcineurin activates NFAT - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2025890] Calcineurin binds NFATC1,2,3 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [Complex:R-CFA-2025977] Calcineurin (CaN) [cytosol] [Complex:R-CFA-74294] CALM1:4xCa2+ [cytosol] [DefinedSet:R-CFA-2025924] p-NFATC1,2,3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Calcineurin binds NFATC1,2,3
output	[Complex:R-CFA-2025899] Calcineurin:p-NFATC1,2,3 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2025890
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-2025928] Calcineurin activates NFAT
(inferredTo)	[Reaction:R-HSA-2025890] Calcineurin binds NFATC1,2,3

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