Reactome | I-Smad competes with R-Smad1/5/8 for type I receptor

Schema > Reaction > Entries

I-Smad competes with R-Smad1/5/8 for type I receptor Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10244585
displayName	I-Smad competes with R-Smad1/5/8 for type I receptor
eventOf	[Pathway:R-CFA-201451] Signaling by BMP - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
inferredFrom	[Reaction:R-HSA-201475] I-Smad competes with R-Smad1/5/8 for type I receptor - Homo sapiens
input	[Complex:R-CFA-201426] BMP:BMPRII:p-4S-BMPRI [plasma membrane] [DefinedSet:R-CFA-173495] I-SMAD [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	I-Smad competes with R-Smad1/5/8 for type I receptor
output	[Complex:R-CFA-201446] BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-201475
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-201451] Signaling by BMP
(inferredTo)	[Reaction:R-HSA-201475] I-Smad competes with R-Smad1/5/8 for type I receptor

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