Reactome | ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA

Schema > Reaction > Entries

ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10244431] long-chain fatty acid-CoA ligase activity of ACSL1,3,5,6 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10244433
displayName	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA
eventOf	[Pathway:R-CFA-75876] Synthesis of very long-chain fatty acyl-CoAs - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA - Canis familiaris
inferredFrom	[Reaction:R-HSA-201035] ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-3632881] PALM [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O Conversion of palmitic acid to palmitoyl-CoA
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-201035
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-75876] Synthesis of very long-chain fatty acyl-CoAs
(precedingEvent)	[Reaction:R-CFA-548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA
(inferredTo)	[Reaction:R-HSA-201035] ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA

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