Reactome | 25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA

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25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10242289] acyl-CoA oxidase activity of ACOX2:FAD [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10242388
displayName	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA
eventOf	[Pathway:R-CFA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Canis familiaris
inferredFrom	[Reaction:R-HSA-193369] 25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-193442] 25(S) DHCA-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-113535] O2 [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA 25(S) DHCA-CoA + O2 => 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O2
output	[SimpleEntity:R-ALL-193459] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-113575] H2O2 [peroxisomal matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-193369
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)	[Reaction:R-CFA-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
(inferredTo)	[Reaction:R-HSA-193369] 25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA

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