Reactome | CYP11A1 cleaves 20a,22b-DHCHOL

Schema > Reaction > Entries

CYP11A1 cleaves 20a,22b-DHCHOL Show undefined attributes

catalystActivity	[CatalystActivity:10242338] cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10242377
displayName	CYP11A1 cleaves 20a,22b-DHCHOL
eventOf	[Pathway:R-CFA-211976] Endogenous sterols - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193101] CYP11A1 cleaves 20a,22b-DHCHOL - Homo sapiens
input	[SimpleEntity:R-ALL-193086] 20a,22b-DHCHOL [mitochondrial inner membrane] 2 × [Complex:R-CFA-5580249] CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP11A1 cleaves 20a,22b-DHCHOL (20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced (adrenodoxin) => 4-methylpentanal + 2 H2O + 2 oxidized (adrenodoxin) + pregnenolone 20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde 20alpha,22beta-hydroxycholesterol + NADPH + H+ + O2 => pregnenolone + isocaproaldehyde + NADP+ + H2O
output	2 × [Complex:R-CFA-5580259] CYP11A1:FDXR:FDX1,FDX1L (ox.) [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-193046] ISCAL [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix] [SimpleEntity:R-ALL-193164] PREG [mitochondrial matrix]
precedingEvent	[Reaction:R-CFA-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-193101
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-211976] Endogenous sterols [Pathway:R-CFA-196108] Pregnenolone biosynthesis
(inferredTo)	[Reaction:R-HSA-193101] CYP11A1 cleaves 20a,22b-DHCHOL

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