Reactome | CYP46A1 24-hydroxylates CHOL

Schema > Reaction > Entries

CYP46A1 24-hydroxylates CHOL Show undefined attributes

catalystActivity	[CatalystActivity:10242239] cholesterol 24-hydroxylase activity of CYP46A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10242241
displayName	CYP46A1 24-hydroxylates CHOL
eventOf	[Pathway:R-CFA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Canis familiaris [Pathway:R-CFA-211976] Endogenous sterols - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-192061] CYP46A1 24-hydroxylates CHOL - Homo sapiens
input	[SimpleEntity:R-ALL-193384] CHOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP46A1 24-hydroxylates CHOL cholesterol + O2 + reduced (NADPH--hemoprotein reductase) => (24S)-hydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O
output	[SimpleEntity:R-ALL-192060] 24OH-CHOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-192061
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol [Pathway:R-CFA-211976] Endogenous sterols
(inferredTo)	[Reaction:R-HSA-192061] CYP46A1 24-hydroxylates CHOL

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