Reactome | FGFR4 binds to FGF

Schema > Reaction > Entries

FGFR4 binds to FGF Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10241618
displayName	FGFR4 binds to FGF
eventOf	[Pathway:R-CFA-190322] FGFR4 ligand binding and activation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-190326] Autocatalytic phosphorylation of FGFR4 - Canis familiaris
inferredFrom	[Reaction:R-HSA-190265] FGFR4 binds to FGF - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-CFA-189921] FGFR4 [plasma membrane] 2 × [DefinedSet:R-CFA-189959] FGFR4-binding FGFs [extracellular region] [SimpleEntity:R-ALL-190915] HS [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	FGFR4 binds to FGF
output	[Complex:R-CFA-190223] FGFR4 homodimer bound to FGF [plasma membrane]
regulatedBy	[Requirement:R-HSA-190318] Requirement by 'HS [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-190265
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-190322] FGFR4 ligand binding and activation
(precedingEvent)	[Reaction:R-CFA-190326] Autocatalytic phosphorylation of FGFR4
(inferredTo)	[Reaction:R-HSA-190265] FGFR4 binds to FGF