Reactome | SCF(Skp2)-mediated degradation of p27/p21

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SCF(Skp2)-mediated degradation of p27/p21 Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329619
displayName	SCF(Skp2)-mediated degradation of p27/p21
eventOf	[Pathway:R-CFA-69656] Cyclin A:Cdk2-associated events at S phase entry - Canis familiaris [Pathway:R-CFA-69202] Cyclin E associated events during G1/S transition - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Canis familiaris [Reaction:R-CFA-187552] Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex - Canis familiaris [Reaction:R-CFA-187575] Ubiquitination of phospho-p27/p21 - Canis familiaris [BlackBoxEvent:R-CFA-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Canis familiaris
inferredFrom	[Pathway:R-HSA-187577] SCF(Skp2)-mediated degradation of p27/p21 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SCF(Skp2)-mediated degradation of p27/p21
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-187577
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-69656] Cyclin A:Cdk2-associated events at S phase entry [Pathway:R-CFA-69202] Cyclin E associated events during G1/S transition
(inferredTo)	[Pathway:R-HSA-187577] SCF(Skp2)-mediated degradation of p27/p21

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