Reactome | Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-187565] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-187552] Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10241200
displayName	Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm]
hasComponent	[DefinedSet:R-CFA-8848491] CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] [DefinedSet:R-CFA-187849] p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-187522] Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] - Homo sapiens
maxDepth	5
name	Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B
producedByEvent	[Reaction:R-CFA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-187522
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-CFA-187552] Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
(output)	[Reaction:R-CFA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
(hasComponent)	[Complex:R-CFA-187565] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm]
(inferredTo)	[Complex:R-HSA-187522] Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm]

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