Reactome | Sprouty lures CBL away from EGFR

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10240913
displayName	Sprouty lures CBL away from EGFR
eventOf	[Pathway:R-CFA-182971] EGFR downregulation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-182988] Sprouty lures CBL away from EGFR - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-112199] CBL [cytosol] [EntityWithAccessionedSequence:R-CFA-182950] phospho-SPRY2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Sprouty lures CBL away from EGFR
output	[Complex:R-CFA-182914] CBL:SPRY1/2 [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-182988
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-182971] EGFR downregulation
(inferredTo)	[BlackBoxEvent:R-HSA-182988] Sprouty lures CBL away from EGFR

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