Reactome | RIP-mediated NFkB activation via ZBP1

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329411
displayName	RIP-mediated NFkB activation via ZBP1
eventOf	[Pathway:R-CFA-1606322] ZBP1(DAI) mediated induction of type I IFNs - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Canis familiaris [Reaction:R-CFA-9604480] NFkB complex translocates from the cytosol to the nucleus - Canis familiaris
inferredFrom	[Pathway:R-HSA-1810476] RIP-mediated NFkB activation via ZBP1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RIP-mediated NFkB activation via ZBP1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-1810476
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-1606322] ZBP1(DAI) mediated induction of type I IFNs
(inferredTo)	[Pathway:R-HSA-1810476] RIP-mediated NFkB activation via ZBP1

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