Reactome | SMAD7 binds to SMURF2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10240759
displayName	SMAD7 binds to SMURF2
eventOf	[Pathway:R-CFA-2173788] Downregulation of TGF-beta receptor signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-178208] SMAD7 binds to SMURF2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-178197] SMAD7 [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-178202] SMURF2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SMAD7 binds to SMURF2
output	[Complex:R-CFA-2167870] SMAD7:SMURF2 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-178208
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-2173788] Downregulation of TGF-beta receptor signaling
(inferredTo)	[Reaction:R-HSA-178208] SMAD7 binds to SMURF2