Reactome | PAPSS1,2 transfer SO4(2-) group to ATP to form APS

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PAPSS1,2 transfer SO4(2-) group to ATP to form APS Show undefined attributes

catalystActivity	[CatalystActivity:10239886] sulfate adenylyltransferase (ATP) activity of PAPSS1,2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10239888
displayName	PAPSS1,2 transfer SO4(2-) group to ATP to form APS
eventOf	[Pathway:R-CFA-174362] Transport and metabolism of PAPS - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Canis familiaris [Reaction:R-CFA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:80800] 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
inferredFrom	[Reaction:R-HSA-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-174375] SO4(2-) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PAPSS1,2 transfer SO4(2-) group to ATP to form APS ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate Activation of inorganic sulfate forms APS
output	[SimpleEntity:R-ALL-174370] APS [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-CFA-427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol - Canis familiaris [Reaction:R-CFA-9941470] SLC26A11 imports SO4(2-) and H+ into cytosol - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-174392
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-174362] Transport and metabolism of PAPS
(precedingEvent)	[Reaction:R-CFA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS [Reaction:R-CFA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate
(inferredTo)	[Reaction:R-HSA-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS

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