Reactome | Cdc20:Phospho-APC/C mediated degradation of Cyclin A

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Cdc20:Phospho-APC/C mediated degradation of Cyclin A Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329507
displayName	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
eventOf	[Pathway:R-CFA-179419] APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-CFA-174154] APC/C:Cdc20 mediated degradation of Securin - Canis familiaris [Pathway:R-CFA-174048] APC/C:Cdc20 mediated degradation of Cyclin B - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:161960] anaphase-promoting complex-dependent catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-174171] Association of Cyclin A with the APC/C - Canis familiaris [Reaction:R-CFA-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex - Canis familiaris [BlackBoxEvent:R-CFA-174255] Degradation multiubiquitinated Cyclin A - Canis familiaris
inferredFrom	[Pathway:R-HSA-174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-174184
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-179419] APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(precedingEvent)	[Pathway:R-CFA-174154] APC/C:Cdc20 mediated degradation of Securin [Pathway:R-CFA-174048] APC/C:Cdc20 mediated degradation of Cyclin B
(inferredTo)	[Pathway:R-HSA-174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A

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