Reactome | VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

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VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) Show undefined attributes

catalystActivity	[CatalystActivity:10236759] vitamin-K-epoxide reductase (warfarin-sensitive) activity of VKORC1 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10236763
displayName	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)
eventOf	[Pathway:R-CFA-6806664] Metabolism of vitamin K - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-159752] GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) - Canis familiaris [Reaction:R-CFA-159795] GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) - Canis familiaris [Reaction:R-CFA-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Canis familiaris [Reaction:R-CFA-159761] GGCX gamma-carboxylates F7(21-466) (pro-factor VII) - Canis familiaris [Reaction:R-CFA-159819] GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) - Canis familiaris [Reaction:R-CFA-6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) - Canis familiaris [Reaction:R-CFA-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Canis familiaris
inferredFrom	[Reaction:R-HSA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - Homo sapiens
input	2 × [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-6806366] MK4 epoxide [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) MK4 epoxide => MK4
output	[SimpleEntity:R-ALL-6806362] MK4 [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-CFA-159752] GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) - Canis familiaris [Reaction:R-CFA-159795] GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) - Canis familiaris [Reaction:R-CFA-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Canis familiaris [Reaction:R-CFA-159761] GGCX gamma-carboxylates F7(21-466) (pro-factor VII) - Canis familiaris [Reaction:R-CFA-159819] GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) - Canis familiaris [Reaction:R-CFA-6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) - Canis familiaris [Reaction:R-CFA-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Canis familiaris
regulatedBy	[NegativeRegulation:10236764] Negative regulation by 'VKORC1 inhibitors:VKORC1 dimer [endoplasmic reticulum membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-159790
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6806664] Metabolism of vitamin K
(precedingEvent)	[Reaction:R-CFA-159752] GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) [Reaction:R-CFA-159795] GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) [Reaction:R-CFA-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) [Reaction:R-CFA-159761] GGCX gamma-carboxylates F7(21-466) (pro-factor VII) [Reaction:R-CFA-159819] GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) [Reaction:R-CFA-6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) [Reaction:R-CFA-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)
(inferredTo)	[Reaction:R-HSA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

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