Reactome | activated thrombin (factor IIa) [extracellular region]

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activated thrombin (factor IIa) [extracellular region] Show undefined attributes

catalystActivities	[CatalystActivity:10235042] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-CFA-140874] thrombin:cleaved SERPINC1 [extracellular region] - Canis familiaris [Complex:R-CFA-5578881] activated thrombin (factor IIa):SERPIND1 [extracellular region] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-9603302] Factor IIa inhibitors (peptide) bind IIa - Canis familiaris [Reaction:R-CFA-9015379] Factor IIa inhibitors (compounds) binds IIa - Canis familiaris [Reaction:R-CFA-5578883] Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) - Canis familiaris [Reaction:R-CFA-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate - Canis familiaris [Reaction:R-CFA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Canis familiaris [Reaction:R-CFA-389463] Proteinase-activated receptors can bind thrombin - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10235041
displayName	activated thrombin (factor IIa) [extracellular region]
hasComponent	6 × [SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [EntityWithAccessionedSequence:R-CFA-140589] F2 [extracellular region] [EntityWithAccessionedSequence:R-CFA-140598] F2 [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-156786] activated thrombin (factor IIa) [extracellular region] - Homo sapiens
maxDepth	2
memberOf	[CandidateSet:R-CFA-8852723] Activated thrombin, (ELANE) [extracellular region] - Canis familiaris [DefinedSet:R-CFA-791492] Ligands of GPCRs that activate Gq/11 [extracellular region] - Canis familiaris
name	activated thrombin (factor IIa)
producedByEvent	[Reaction:R-CFA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Canis familiaris [Reaction:R-CFA-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-156786
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-CFA-9603302] Factor IIa inhibitors (peptide) bind IIa [Reaction:R-CFA-9015379] Factor IIa inhibitors (compounds) binds IIa [Reaction:R-CFA-5578883] Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) [Reaction:R-CFA-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate [Reaction:R-CFA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin [Reaction:R-CFA-389463] Proteinase-activated receptors can bind thrombin
(output)	[Reaction:R-CFA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Reaction:R-CFA-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
(hasComponent)	[Complex:R-CFA-140874] thrombin:cleaved SERPINC1 [extracellular region] [Complex:R-CFA-5578881] activated thrombin (factor IIa):SERPIND1 [extracellular region] [Complex:R-CFA-9603322] Factor IIa inhibitors (peptide):IIa [extracellular region] [Complex:R-CFA-9015343] Factor IIa inhibitors (compounds):IIa [extracellular region] [Complex:R-CFA-389470] Thrombin:Proteinase-activated receptors [plasma membrane]
(hasMember)	[CandidateSet:R-CFA-8852723] Activated thrombin, (ELANE) [extracellular region] [DefinedSet:R-CFA-791492] Ligands of GPCRs that activate Gq/11 [extracellular region]
(physicalEntity)	[CatalystActivity:10235042] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
(inferredTo)	[Complex:R-HSA-156786] activated thrombin (factor IIa) [extracellular region]

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