Reactome | 2-acyl LPI is acylated to PI by MBOAT7

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2-acyl LPI is acylated to PI by MBOAT7 Show undefined attributes

catalystActivity	[CatalystActivity:10142142] 2-acylglycerol-3-phosphate O-acyltransferase activity of MBOAT7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10142144
displayName	2-acyl LPI is acylated to PI by MBOAT7
eventOf	[Pathway:R-CFA-1482922] Acyl chain remodelling of PI - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] - Canis familiaris [Reaction:R-CFA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Canis familiaris [Reaction:R-CFA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Canis familiaris [Reaction:R-CFA-1483219] PC is exchanged with PI by PITPNB - Canis familiaris
inferredFrom	[Reaction:R-HSA-1482626] 2-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens
input	[SimpleEntity:R-ALL-1498737] 2-acyl LPI [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isInDisease	false
isInferred	true
name	2-acyl LPI is acylated to PI by MBOAT7
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-CFA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] - Canis familiaris
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1482626
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1482922] Acyl chain remodelling of PI
(precedingEvent)	[Reaction:R-CFA-1483219] PC is exchanged with PI by PITPNB [Reaction:R-CFA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane [Reaction:R-CFA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] [Reaction:R-CFA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13]
(inferredTo)	[Reaction:R-HSA-1482626] 2-acyl LPI is acylated to PI by MBOAT7