Reactome | PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)

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PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) Show undefined attributes

catalystActivity	[CatalystActivity:10268715] A2-type glycerophospholipase activity of PLA2(1) [cytosol]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10268717
displayName	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
eventOf	[Pathway:R-CFA-1483166] Synthesis of PA - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1482548] 1-acyl LPA is acylated to PA by AGPAT5 (OM) - Canis familiaris
inferredFrom	[Reaction:R-HSA-1482604] PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1500590] PA [mitochondrial outer membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
output	[SimpleEntity:R-ALL-1500580] 1-acyl LPA [mitochondrial outer membrane] [SimpleEntity:R-ALL-1524103] LCFA(-) [mitochondrial outer membrane]
precedingEvent	[Reaction:R-CFA-1482548] 1-acyl LPA is acylated to PA by AGPAT5 (OM) - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1482604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1483166] Synthesis of PA
(inferredTo)	[Reaction:R-HSA-1482604] PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
(precedingEvent)	[Reaction:R-CFA-1482548] 1-acyl LPA is acylated to PA by AGPAT5 (OM)

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