Reactome | JAK2 binds to p-KIT

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JAK2 binds to p-KIT Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10267444
displayName	JAK2 binds to p-KIT
eventOf	[Pathway:R-CFA-1433557] Signaling by SCF-KIT - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1433418] Phosphorylation of JAK2 - Canis familiaris
inferredFrom	[Reaction:R-HSA-1433451] JAK2 binds to p-KIT - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-CFA-210620] JAK2 [cytosol] [Complex:R-CFA-205271] SFKs:p-KIT complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK2 binds to p-KIT
output	[Complex:R-CFA-1433493] JAK2:SFKS:p-KIT complex [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1433451
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1433557] Signaling by SCF-KIT
(precedingEvent)	[Reaction:R-CFA-1433418] Phosphorylation of JAK2
(inferredTo)	[Reaction:R-HSA-1433451] JAK2 binds to p-KIT

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