Reactome | MTA is cleaved and phosphorylated

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MTA is cleaved and phosphorylated Show undefined attributes

catalystActivity	[CatalystActivity:10266319] S-methyl-5-thioadenosine phosphorylase activity of MTAP trimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10266321
displayName	MTA is cleaved and phosphorylated
eventOf	[Pathway:R-CFA-1237112] Methionine salvage pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1237096] Methylthio-ribose-P => Methylthio-ribulose-P - Canis familiaris
inferredFrom	[Reaction:R-HSA-1237160] MTA is cleaved and phosphorylated - Homo sapiens
input	[SimpleEntity:R-ALL-353106] MTAD [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MTA is cleaved and phosphorylated phosphate + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
output	[SimpleEntity:R-ALL-83951] Ade [cytosol] [SimpleEntity:R-ALL-1237165] MTRIBP [cytosol]
precedingEvent	[Reaction:R-CFA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine - Canis familiaris [Reaction:R-CFA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1237160
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1237112] Methionine salvage pathway
(precedingEvent)	[Reaction:R-CFA-1237096] Methylthio-ribose-P => Methylthio-ribulose-P
(inferredTo)	[Reaction:R-HSA-1237160] MTA is cleaved and phosphorylated

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