Reactome | CA4:Zn2+ dehydrates HCO3- to CO2

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CA4:Zn2+ dehydrates HCO3- to CO2 Show undefined attributes

catalystActivity	[CatalystActivity:10266278] carbonate dehydratase activity of CA4:Zn2+ [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10266282
displayName	CA4:Zn2+ dehydrates HCO3- to CO2
eventOf	[Pathway:R-CFA-1247673] Erythrocytes take up oxygen and release carbon dioxide - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1237059] CA4:Zn2+ dehydrates HCO3- to CO2 - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-425425] HCO3- [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	CA4:Zn2+ dehydrates HCO3- to CO2 Carbonic anhydrase IV dehydrates bicarbonate to water and carbon dioxide H+ + HCO3- -> H2O + CO2
output	[SimpleEntity:R-ALL-1237009] CO2 [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
precedingEvent	[Reaction:R-CFA-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1237059
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1247673] Erythrocytes take up oxygen and release carbon dioxide
(inferredTo)	[Reaction:R-HSA-1237059] CA4:Zn2+ dehydrates HCO3- to CO2

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