Reactome | Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B

Schema > Reaction > Entries

Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10265671
displayName	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B
eventOf	[Pathway:R-CFA-1502540] Signaling by Activin - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin - Canis familiaris
inferredFrom	[Reaction:R-HSA-1181153] Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B - Homo sapiens
input	[DefinedSet:R-CFA-2470494] Activin A,AB,B [extracellular region] 2 × [EntityWithAccessionedSequence:R-CFA-205867] ACVR1B [plasma membrane] 2 × [DefinedSet:R-CFA-1181136] ACVR2A,B [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B
output	[Complex:R-CFA-1549493] Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane]
regulatedBy	[NegativeRegulation:10244573] Negative regulation by 'INHIBIN-A:TGFBR3:ACVR2A [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1181153
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1502540] Signaling by Activin
(precedingEvent)	[Reaction:R-CFA-1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin
(inferredTo)	[Reaction:R-HSA-1181153] Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B

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