Reactome | Formation of apoptosome

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Formation of apoptosome Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329101
displayName	Formation of apoptosome
eventOf	[Pathway:R-CFA-111461] Cytochrome c-mediated apoptotic response - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-CFA-111459] Activation of caspases through apoptosome-mediated cleavage - Canis familiaris
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-114254] CYCS binds to APAF1 - Canis familiaris [Reaction:R-CFA-114256] CYCS:APAF1 binds procaspase-9 - Canis familiaris [Reaction:R-CFA-9627056] Procaspase 9 forms dimer - Canis familiaris [Reaction:R-CFA-114259] Cleavage of Procaspase?9 to caspase?9 - Canis familiaris [Pathway:R-CFA-9627069] Regulation of the apoptosome activity - Canis familiaris
inferredFrom	[Pathway:R-HSA-111458] Formation of apoptosome - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Formation of apoptosome
precedingEvent	[Reaction:R-CFA-114284] Release of Cytochrome c from mitochondria - Canis familiaris
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-111458
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-111461] Cytochrome c-mediated apoptotic response
(precedingEvent)	[Pathway:R-CFA-111459] Activation of caspases through apoptosome-mediated cleavage
(inferredTo)	[Pathway:R-HSA-111458] Formation of apoptosome