Reactome | PTPN11 binds p-Y759-IL6ST

Schema > Reaction > Entries

PTPN11 binds p-Y759-IL6ST Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10265481
displayName	PTPN11 binds p-Y759-IL6ST
eventOf	[Pathway:R-CFA-1059683] Interleukin-6 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1112703] PTPN11 is phosphorylated - Canis familiaris [Reaction:R-CFA-1112690] PTPN11 binds CBL - Canis familiaris
inferredFrom	[Reaction:R-HSA-1112708] PTPN11 binds p-Y759-IL6ST - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-162563] PTPN11 [cytosol] [Complex:R-CFA-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PTPN11 binds p-Y759-IL6ST SHP2 binds IL6ST phosphotyrosine-759
output	[Complex:R-CFA-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-CFA-1112510] IL6ST is tyrosine phosphorylated - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1112708
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1059683] Interleukin-6 signaling
(precedingEvent)	[Reaction:R-CFA-1112703] PTPN11 is phosphorylated [Reaction:R-CFA-1112690] PTPN11 binds CBL
(inferredTo)	[Reaction:R-HSA-1112708] PTPN11 binds p-Y759-IL6ST

Cite Us!