Reactome | Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor

Schema > Reaction > Entries

Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor Show undefined attributes

catalystActivity	[CatalystActivity:10265440] non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10265444
displayName	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
eventOf	[Pathway:R-CFA-1059683] Interleukin-6 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-1112727] Serine phosphorylation of STATs - Canis familiaris [Reaction:R-CFA-1112604] Phosphorylated STATs are released - Canis familiaris
inferredFrom	[Reaction:R-HSA-1112602] Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-1112576] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-1112524] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane]
precedingEvent	[Reaction:R-CFA-1112565] Tyrosine phosphorylated IL6ST binds STAT1,STAT3 - Canis familiaris
regulatedBy	[NegativeRegulation:10265445] Negative regulation by 'Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1112602
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1059683] Interleukin-6 signaling
(precedingEvent)	[BlackBoxEvent:R-CFA-1112727] Serine phosphorylation of STATs [Reaction:R-CFA-1112604] Phosphorylated STATs are released
(inferredTo)	[Reaction:R-HSA-1112602] Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor