Reactome | Cleavage of thymine glycol by NTHL1 glycosylase

Schema > Reaction > Entries

Cleavage of thymine glycol by NTHL1 glycosylase Show undefined attributes

catalystActivity	[CatalystActivity:10233656] oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1:Tg-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10233658
displayName	Cleavage of thymine glycol by NTHL1 glycosylase
eventOf	[Pathway:R-CFA-110329] Cleavage of the damaged pyrimidine - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Canis familiaris
inferredFrom	[Reaction:R-HSA-110224] Cleavage of thymine glycol by NTHL1 glycosylase - Homo sapiens
input	[Complex:R-CFA-110177] NTHL1:Tg-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of thymine glycol by NTHL1 glycosylase
output	[Complex:R-CFA-110193] NTHL1:AP-dsDNA [nucleoplasm] [SimpleEntity:R-ALL-110223] Tg [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-110224
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CFA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site
(hasEvent)	[Pathway:R-CFA-110329] Cleavage of the damaged pyrimidine
(inferredTo)	[Reaction:R-HSA-110224] Cleavage of thymine glycol by NTHL1 glycosylase

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