Reactome | IL6:IL6R-2 [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-CFA-1067674] IL6:IL6R-2:IL6ST-2 [extracellular region] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-1067676] IL6:IL6R-2 binds IL6ST-2 - Canis familiaris [Reaction:R-CFA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10233504
displayName	IL6:IL6R-2 [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-CFA-447100] IL6 [extracellular region] [EntityWithAccessionedSequence:R-CFA-1067661] IL6R [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-1067687] IL6:IL6R-2 [extracellular region] - Homo sapiens
maxDepth	2
name	IL6:IL6R-2
producedByEvent	[Reaction:R-CFA-1067640] IL6 binds IL6R-2 - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-1067687
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-CFA-1067676] IL6:IL6R-2 binds IL6ST-2 [Reaction:R-CFA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
(output)	[Reaction:R-CFA-1067640] IL6 binds IL6R-2
(hasComponent)	[Complex:R-CFA-1067674] IL6:IL6R-2:IL6ST-2 [extracellular region] [Complex:R-CFA-1067691] IL6:sIL6R:IL6RB:JAKs [plasma membrane] [Complex:R-CFA-1112513] IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] [Complex:R-CFA-1112570] IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]
(inferredTo)	[Complex:R-HSA-1067687] IL6:IL6R-2 [extracellular region]