Reactome | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV

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BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10996113
displayName	BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
eventOf	[Pathway:R-CEL-70895] Branched-chain amino acid catabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV - Caenorhabditis elegans [Reaction:R-CEL-9859163] DBT transfers BCAA to CoA - Caenorhabditis elegans [Reaction:R-CEL-9859172] DLD dimer dehydrogenates dihydrolipoyl - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-9859138] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+ Oxidative decarboxylation of branched-chain alpha-keto acids
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9859138
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-70895] Branched-chain amino acid catabolism
(inferredTo)	[Pathway:R-HSA-9859138] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV

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