Reactome | Sphingolipid catabolism

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Sphingolipid catabolism Show undefined attributes

compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10994739
displayName	Sphingolipid catabolism
eventOf	[Pathway:R-CEL-428157] Sphingolipid metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20501] sphingolipid catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) - Caenorhabditis elegans [Reaction:R-CEL-428205] ACER2 hydrolyzes ceramide (Golgi) - Caenorhabditis elegans [Reaction:R-CEL-428681] PXLP-SGPL1 cleaves sphingoid-1-phosphates - Caenorhabditis elegans [Reaction:R-CEL-428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate - Caenorhabditis elegans [Reaction:R-CEL-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Caenorhabditis elegans [Reaction:R-CEL-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Caenorhabditis elegans [Reaction:R-CEL-5696080] ALDH3B1 oxidises HXAL to PALM - Caenorhabditis elegans [Reaction:R-CEL-6808464] ALDH3B2 oxidises HXAL to PALM - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-9845614] Sphingolipid catabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Sphingolipid catabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9845614
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-428157] Sphingolipid metabolism
(inferredTo)	[Pathway:R-HSA-9845614] Sphingolipid catabolism