Reactome | AFG3L2 binds mitochondrial matrix proteins

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AFG3L2 binds mitochondrial matrix proteins Show undefined attributes

category	binding
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10991065
displayName	AFG3L2 binds mitochondrial matrix proteins
eventOf	[Pathway:R-CEL-9837999] Mitochondrial protein degradation - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CEL-9839105] AFG3L2 degrades mitochondrial matrix proteins - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-9839149] AFG3L2 binds mitochondrial matrix proteins - Homo sapiens
input	[Complex:R-CEL-9838620] AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] [DefinedSet:R-CEL-9839078] Substrate of AFG3L2 (mitochondrial matrix) [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	AFG3L2 binds mitochondrial matrix proteins
output	[Complex:R-CEL-9839083] AFG3L2:substrate protein (mitochondrial matrix) [mitochondrial inner membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9839149
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9837999] Mitochondrial protein degradation
(precedingEvent)	[BlackBoxEvent:R-CEL-9839105] AFG3L2 degrades mitochondrial matrix proteins
(inferredTo)	[Reaction:R-HSA-9839149] AFG3L2 binds mitochondrial matrix proteins

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