Reactome | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

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GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10996059
displayName	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
eventOf	[Pathway:R-CEL-9759194] Nuclear events mediated by NFE2L2 - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-9762094] GSK3B phosphorylates p-NFE2L2 - Caenorhabditis elegans [Reaction:R-CEL-9762093] BTRC binds p-S344, 347 NFE2L2 - Caenorhabditis elegans [Reaction:R-CEL-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 - Caenorhabditis elegans [BlackBoxEvent:R-CEL-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9762114
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9759194] Nuclear events mediated by NFE2L2
(inferredTo)	[Pathway:R-HSA-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

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