Reactome | GGT dimers hydrolyse APAP-SG

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GGT dimers hydrolyse APAP-SG Show undefined attributes

catalystActivity	[CatalystActivity:10965758] glutathione gamma-glutamate hydrolase activity of GGT dimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10989104
displayName	GGT dimers hydrolyse APAP-SG
eventOf	[Pathway:R-CEL-9753281] Paracetamol ADME - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-9753634] GGT dimers hydrolyse APAP-SG - Homo sapiens
input	[SimpleEntity:R-ALL-9753685] APAP-SG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GGT dimers hydrolyse APAP-SG
output	[SimpleEntity:R-ALL-9753680] APAP-CysGly [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
precedingEvent	[Reaction:R-CEL-9753280] GSTs transfer GSH to NAPQI to form APAP-SG - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9753634
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9753281] Paracetamol ADME
(precedingEvent)	[Reaction:R-CEL-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly
(inferredTo)	[Reaction:R-HSA-9753634] GGT dimers hydrolyse APAP-SG

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