Reactome | ABCC4 transports TPMP substrates from cytosol to extracellular region

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ABCC4 transports TPMP substrates from cytosol to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:10989059] ATPase-coupled transmembrane transporter activity of ABCC4 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10989061
displayName	ABCC4 transports TPMP substrates from cytosol to extracellular region
eventOf	[Pathway:R-CEL-9748787] Azathioprine ADME - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:22548] xenobiotic transmembrane transport
inferredFrom	[Reaction:R-HSA-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region - Homo sapiens
input	[DefinedSet:R-ALL-9750587] ABCC4 TPMP substrates [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCC4 transports TPMP substrates from cytosol to extracellular region ABCC4 transports thiopurine monophosphates from cytosol to extracellular region
output	[DefinedSet:R-ALL-9750548] ABCC4 TPMP substrates [extracellular region] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-CEL-9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP - Caenorhabditis elegans [Reaction:R-CEL-9748957] GMPS dimer transforms 6TXMP to 6TGMP - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9750546
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9748787] Azathioprine ADME
(inferredTo)	[Reaction:R-HSA-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region

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