Reactome | CES1,CES2 hydrolyze ASA- to ST

Schema > Reaction > Entries

CES1,CES2 hydrolyze ASA- to ST Show undefined attributes

catalystActivity	[CatalystActivity:10970974] carboxylic ester hydrolase activity of CES1 trimer, CES2 [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10989052
displayName	CES1,CES2 hydrolyze ASA- to ST
eventOf	[Pathway:R-CEL-9749641] Aspirin ADME - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-9749986] CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA - Caenorhabditis elegans [Reaction:R-CEL-9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-9749792] CES1,CES2 hydrolyze ASA- to ST - Homo sapiens
input	[SimpleEntity:R-ALL-9749795] ASA- (hepatocyte) [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CES1,CES2 hydrolyze ASA- to ST
output	[SimpleEntity:R-ALL-9749588] acetate [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-9749790] ST (hepatocyte) [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9749792
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9749641] Aspirin ADME
(precedingEvent)	[Reaction:R-CEL-9749986] CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA [Reaction:R-CEL-9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA
(inferredTo)	[Reaction:R-HSA-9749792] CES1,CES2 hydrolyze ASA- to ST