Reactome | PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated

Schema > Reaction > Entries

PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10985531
displayName	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated
eventOf	[Pathway:R-CEL-8964616] G beta:gamma signalling through CDC42 - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-8964599] Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-8964614] PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated - Homo sapiens
input	[Complex:R-CEL-9014577] G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated
output	[Complex:R-CEL-9014577] G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane]
precedingEvent	[Reaction:R-CEL-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8964614
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8964616] G beta:gamma signalling through CDC42
(precedingEvent)	[Reaction:R-CEL-8964599] Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
(inferredTo)	[Reaction:R-HSA-8964614] PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated

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