Reactome | p-VAV family:PIP3 binds RAC1:GDP

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p-VAV family:PIP3 binds RAC1:GDP Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10984578
displayName	p-VAV family:PIP3 binds RAC1:GDP
eventOf	[Pathway:R-CEL-4420097] VEGFA-VEGFR2 Pathway - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-8951586] p-VAV family:PIP3 binds RAC1:GDP - Homo sapiens
input	[Complex:R-CEL-5218789] p-VAV family:PIP3 [plasma membrane] [Complex:R-CEL-5674631] RAC1:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-VAV family:PIP3 binds RAC1:GDP
output	[Complex:R-CEL-8951587] p-VAV family:PIP3:RAC1:GDP [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8951586
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-CEL-5218850] VAV exchanges GTP for GDP on RAC1, activating it
(inferredTo)	[Reaction:R-HSA-8951586] p-VAV family:PIP3 binds RAC1:GDP

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