Reactome | MET phosphorylates CBL

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MET phosphorylates CBL Show undefined attributes

catalystActivity	[CatalystActivity:10982733] protein tyrosine kinase activity of HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10982735
displayName	MET phosphorylates CBL
eventOf	[Pathway:R-CEL-6807004] Negative regulation of MET activity - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-8875183] CBL monoubiquitinates activated MET - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-8875451] MET phosphorylates CBL - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CEL-8876358] HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MET phosphorylates CBL
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CEL-8876357] HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8875451
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-6807004] Negative regulation of MET activity
(precedingEvent)	[Reaction:R-CEL-8875183] CBL monoubiquitinates activated MET
(inferredTo)	[Reaction:R-HSA-8875451] MET phosphorylates CBL