Reactome | Clathrin recruits PIK3C2A

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Clathrin recruits PIK3C2A Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10981806
displayName	Clathrin recruits PIK3C2A
eventOf	[Pathway:R-CEL-8856828] Clathrin-mediated endocytosis - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Caenorhabditis elegans [Reaction:R-CEL-8867754] F- and N- BAR domain proteins bind the clathrin-coated pit - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-8868071] Clathrin recruits PIK3C2A - Homo sapiens
input	[Complex:R-CEL-8867753] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] [EntityWithAccessionedSequence:R-CEL-1604624] piki-1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Clathrin recruits PIK3C2A
output	[Complex:R-CEL-8868051] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane]
precedingEvent	[Reaction:R-CEL-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8868071
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-CEL-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 [Reaction:R-CEL-8867754] F- and N- BAR domain proteins bind the clathrin-coated pit
(inferredTo)	[Reaction:R-HSA-8868071] Clathrin recruits PIK3C2A