Reactome | VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1

Schema > Reaction > Entries

VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10980759
displayName	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1
eventOf	[Pathway:R-CEL-8853884] Transcriptional Regulation by VENTX - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8853965] VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 - Homo sapiens
input	[Complex:R-CEL-8853944] CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm] [DefinedSet:R-CEL-8853887-4] Homologues of VENTX [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1
output	[EntityWithAccessionedSequence:R-CEL-3451168] hmp-2 [nucleoplasm] [Complex:R-CEL-8853962] VENTX:TCF4,LEF1:CCND1 Gene [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8853965
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8853884] Transcriptional Regulation by VENTX
(inferredTo)	[Reaction:R-HSA-8853965] VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1

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