Reactome | Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol

Schema > Reaction > Entries

Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10980657] ubiquitin activating enzyme activity of Ub-Cys632-UBA1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10980659
displayName	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol
eventOf	[Pathway:R-CEL-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-CEL-113595] Ub [cytosol] [Complex:R-CEL-8852063] Ub-Cys632-UBA1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol
output	[SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-CEL-8852079] Ub-Cys632-UBA1:ubiquitin adenylate [cytosol]
precedingEvent	[Reaction:R-CEL-8852133] UBA1 conjugates ubiquitin to UBA1 in the cytosol - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8852132
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes
(precedingEvent)	[Reaction:R-CEL-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes
(inferredTo)	[Reaction:R-HSA-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol

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